Britain's Andy Murray was knocked out in the second round of the European Open in Antwerp by world number 14 Diego Schwartzman.
The Argentine, 29, came from 4-1 behind to take the first set before winning a tight battle in the second to go through 6-4 7-6 (8-6).
Murray fought back from 4-2 down in the second set to force a tie-break.
Momentum fluctuated in the breaker, with Murray saving one match point before Schwartzman edged home.
Murray - who won this event in 2019 just nine months after pioneering hip resurfacing surgery - edged past Frances Tiafoe in a thrilling first-round match to set up a first-time meeting with Schwartzman.
The Argentine was full of respect for Murray in his post-match comments.
"It was a pleasure to play against Andy," said Schwartzman, who reached back-to-back finals in Antwerp in 2016 and 2017.
"We had not played before and he is coming back and every week he is playing better and moving better.
"I have a lot of respect because when I grew up playing tennis, I was watching Roger Federer, Rafael Nadal, Andy Murray and Novak Djokovic and right now, playing against him is a pleasure for me."