Asmir Begovic was beaten by a big deflection for Bournemouth's openerBournemouth thrashed Everton in a meeting of much-changed Premier League sides in the Carabao Cup third round.
Blues boss Frank Lampard made 11 changes, and his side lost to a team with nine alterations from the weekend.
The Cherries led via Jamal Lowe's deflected shot, and Junior Stanislas finished following a defensive error.
Substitute Demarai Gray pulled one back for Everton, before Emiliano Marcondes and Jaidon Anthony secured Bournemouth's place in the last 16.
Lampard loses in reserves gamble
Bournemouth boss Gary O'Neil and Everton counterpart Lampard made wholesale changes, with the final round of Premier League games before the 2022 World Cup coming up this weekend.
Only goalkeeper Mark Travers and central defender Chris Mepham kept their places for the hosts from their incredible 4-3 loss at Leeds United on Saturday.
Lampard went even further, completely switching his starting XI from Saturday's defeat by Leicester, including giving a first Everton start for summer signing James Garner.
It was the new-look Cherries who adapted quicker, leading after seven minutes when Lowe's effort struck Nathan Patterson and looped into the net with keeper Asmir Begovic stranded.
Everton had the better of the first-half chances thereafter - inside the opening 16 minutes, Tom Davies blasted a one-on-one over, Travers saved well from Garner and Anthony Gordon misdirected a header over the bar from six yards.
Gordon then should have been sent off for a two-footed lunge on Jordan Zemura shortly before half-time, but instead got away with his seventh booking in 14 games this season and should be thankful for the lack of VAR in EFL Cup matches.
Everton's supporters voiced their displeasure at Lampard throughout the game for his decision to make so many changes, upset at the chance of a first major trophy since 1995 being given up.
O'Neil returns to winning ways
Having gone unbeaten in his first six games as interim Bournemouth boss following the sacking of Scott Parker, O'Neil has overseen defeats in each of his past four matches.
However, a cup run will do his chances of a permanent appointment no harm - although had Everton taken their chances it could have been a very different story.
Instead, Everton gifted Bournemouth captain Stanislas a goal on 47 minutes. Mason Holgate slipped as Begovic passed to him, allowing Ryan Christie to steal it.
He squared to Lowe whose shot was blocked by Begovic, however it rebounded to Stanislas to tuck away with covering defender Michael Keane slow to respond.
Stanislas spoke highly of O'Neil after the game, telling BBC Radio Solent: "He's been brilliant for all of us. We've worked with him for a couple of seasons.
"He's done the best he can and we've picked up some really good results. He's always driving us and pushing us.
"We don't know what is going to go on over the winter break but hopefully we can sign off on a high on Saturday."
Lampard threw on Alex Iwobi, Dwight McNeil and Gray to try to rescue the match, and the latter did make an impact on 67 minutes by curling the ball past Travers to make it 2-1.
Bournemouth gave away two-goal leads in their past two Premier League matches, but on this occasion took their chances to secure a comfortable win.
Marcondes slotted from close range before Anthony finished low after Patterson gave the ball away, to further increase O'Neil's chances of keeping the Vitality Stadium manager's job on a full-time basis.
Line-ups
Bournemouth
Formation 4-2-3-1
1Travers
17Stacey3Stephens6Mepham33Zemura
14Rothwell22Pearson
32Anthony19Stanislas10Christie
18Lowe
1Travers17Stacey3StephensBooked at 85mins6Mepham33ZemuraSubstituted forFredericksat 65'minutes14RothwellSubstituted forDembéléat 75'minutes22PearsonBooked at 84mins32AnthonyBooked at 73mins19StanislasSubstituted forMarcondesat 66'minutes10ChristieSubstituted forSadiat 88'minutes18LoweSubstituted forHillat 88'minutesSubstitutes
2Fredericks4L Cook11Marcondes16Tavernier20Dembélé23Hill43Greenwood45Plain49SadiEverton
Formation 3-5-2
15Begovic
5Keane13Mina4Holgate
3Patterson37Garner16Doucouré26Davies29Vinagre
20Maupay10Gordon
15Begovic5Keane13MinaBooked at 84mins4HolgateSubstituted forMcNeilat 51'minutes3Patterson37GarnerSubstituted forIwobiat 52'minutes16DoucouréSubstituted forMillsat 81'minutes26Davies29Vinagre20MaupaySubstituted forCannonat 81'minutes10GordonBooked at 44minsSubstituted forGrayat 52'minutesSubstitutes
7McNeil11Gray17Iwobi31Lonergan47Cannon56Mills59Samuels-Smith60Price64WelchReferee:Darren EnglandAttendance:10,021Live Text
Match ends, Bournemouth 4, Everton 1.
Second Half ends, Bournemouth 4, Everton 1.
Corner, Everton. Conceded by Dominic Sadi.
Nathan Patterson (Everton) wins a free kick in the defensive half.
Foul by Emiliano Marcondes (Bournemouth).
Offside, Everton. Michael Keane tries a through ball, but Stanley Mills is caught offside.
Substitution, Bournemouth. James Hill replaces Jamal Lowe.
Substitution, Bournemouth. Dominic Sadi replaces Ryan Christie.
Alex Iwobi (Everton) wins a free kick in the defensive half.
Foul by Ryan Christie (Bournemouth).
Jack Stephens (Bournemouth) is shown the yellow card for a bad foul.
Thomas Cannon (Everton) wins a free kick on the right wing.
Foul by Jack Stephens (Bournemouth).
Yerry Mina (Everton) is shown the yellow card.
Ben Pearson (Bournemouth) is shown the yellow card.
Foul by Dwight McNeil (Everton).
Ben Pearson (Bournemouth) wins a free kick in the attacking half.
Goal! Bournemouth 4, Everton 1. Jaidon Anthony (Bournemouth) left footed shot from the centre of the box to the bottom right corner. Assisted by Siriki Dembélé.
Substitution, Everton. Thomas Cannon replaces Neal Maupay.
Substitution, Everton. Stanley Mills replaces Abdoulaye Doucouré.
