Roland Sallai scored in either half for Hungary, who are top of Group A3England's dismal Nations League campaign continued as they slumped to their worst home defeat since 1928 against a ruthless Hungary to leave Gareth Southgate's side rooted to the bottom of Group A3.
The Three Lions have now gone four games without a victory for the first time since 2014 and look worryingly out of form and confidence with a World Cup looming at the end of this year.
They could do nothing but capitulate to a humiliating and potentially damaging defeat that had the crowd booing and baying for Southgate's job at the final whistle.
Roland Sallai put the visitors in front with a well-taken finish at the back post, then doubled Hungary's lead with his second on the break 20 minutes from time.
There was more to come from a rampant Hungary, as Zsolt Nagy fired in from range and - after John Stones was sent off to compound a woeful evening for the hosts - Daniel Gazdag finished smartly to wrap up a second historic win over England in 10 days.
Jarrod Bowen had earlier missed a decent chance at the back post from Reece James' cross and Harry Kane flicked a header against the bar, but the hosts once again lacked the belief and inventiveness to open up their opposition.
Hungary - who top a group that also includes Germany and Italy - were well organised and clinical to earn only their second win over the Three Lions on English soil and first since a famous 6-3 success at Wembley in 1953.
Three Lions slump to historic loss
The idea was the Three Lions would be buoyed by a packed and boisterous Molineux, after playing out a goalless draw against Italy in front of a couple of thousand schoolchildren on Saturday, but such is the brittle confidence in this England side at the moment that Hungary's opener knocked them off their stride and they never recovered.
Southgate made nine changes to the side that drew with Italy and England did start with some purpose when Reece James, from left-back, combined well with Kane before lofting a ball to the back post, where Bowen was unable to turn it in.
The West Ham forward should also have done better when England caught the visitors on the break after James had hooked off his own line to stop Hungary doubling their lead.
Substitute Phil Foden dragged an effort wide and Kane flicked a header against the crossbar, but the night belonged to Hungary as they showcased a clinical edge that England have been lacking throughout this international break.
What England have been throughout Southgate's tenure is solid at the back, not conceding more than once in 25 previous games before this one. But as Sallai pounced after Kalvin Phillips lost possession in midfield to double their lead, Nagy slammed in a third and Gazdag added a late fourth, that run was ruthlessly cut to pieces.
It brings a brutal end to a long campaign for these players, who will be grateful to take a break before pre-season begins with their clubs again in a few weeks.
But Southgate will be left to ponder this defeat knowing he has just two games left in September to arrest this slide before England head to the World Cup in Qatar, and also contend with the real possibility of relegation from the top tier of Nations League football.
Magical Rossi takes Hungary top
Marco Rossi has created a resilient and hard-to-beat Hungary side, as England discovered in the opening Nations League game - one who took a point off Germany last time out and sat second in the group before this encounter in Wolverhampton.
But you have to go back to 1953 and the Magical Magyars' famous 6-3 victory at Wembley to find Hungary's only previous victory against the Three Lions on English soil, showing just what a monumental task the Italian is doing with this squad.
Having ground out a 1-0 win over England at the beginning of this international break, they showed that was no fluke with this resilient and clinical performance that delighted the 700 or so visiting fans at Molineux.
While Southgate's job will come into question after this performance, Rossi's stock is surely only on the rise having built a Hungary side who have proved they can mix it with the world's best.
Player of the match
SallaiRoland Sallai
Line-ups
England
Formation 4-3-3
1Ramsdale
2Walker5Stones6Guéhi3James
8Gallagher4Phillips10Bellingham
7Bowen9Kane11Saka
1Ramsdale2WalkerBooked at 85mins5StonesBooked at 82mins6Guéhi3James8GallagherSubstituted forMountat 56'minutes4Phillips10BellinghamSubstituted forFodenat 68'minutes7BowenSubstituted forSterlingat 45'minutes9Kane11SakaSubstituted forMaguireat 85'minutesSubstitutes
12Trippier13Pope14Maguire15Grealish16Coady17Ward-Prowse18Rice19Mount20Sterling21Foden22Pickford23AbrahamHungary
Formation 3-4-2-1
1Dibusz
2Lang6Orban4Szalai
5Fiola13Schäfer17Styles18Nagy
20Sallai10Szoboszlai
9Szalai
1Dibusz2Lang6Orban4Szalai5Fiola13Schäfer17StylesSubstituted forNagyat 56'minutes18NagyBooked at 89mins20SallaiSubstituted forNegoat 78'minutes10SzoboszlaiSubstituted forGazdagat 56'minutes9SzalaiSubstituted forÁdámat 68'minutesSubstitutes
3Kecskés7Nego8Nagy11Schön14Bolla15Kerkez16Gazdag19Ádám21Spandler22Szappanos23VécseiLive Text
Match ends, England 0, Hungary 4.
Second Half ends, England 0, Hungary 4.
Attempt missed. Mason Mount (England) left footed shot from outside the box misses to the right. Assisted by Kalvin Phillips following a corner.
Corner, England. Conceded by Willi Orban.
Zsolt Nagy (Hungary) is shown the yellow card.
Bendegúz Bolla (Hungary) is shown the yellow card for excessive celebration.
Goal! England 0, Hungary 4. Dániel Gazdag (Hungary) left footed shot from the centre of the box to the bottom right corner. Assisted by Ádám Nagy with a through ball following a fast break.
Kalvin Phillips (England) wins a free kick in the defensive half.
Foul by Attila Fiola (Hungary).
Kyle Walker (England) is shown the yellow card for a bad foul.
Foul by Kyle Walker (England).
Loic Nego (Hungary) wins a free kick in the attacking half.
Substitution, England. Harry Maguire replaces Bukayo Saka.
Attempt missed. Phil Foden (England) right footed shot from the right side of the box misses to the left. Assisted by Reece James.
Second yellow card to John Stones (England) for a bad foul.
Foul by John Stones (England).
Dániel Gazdag (Hungary) wins a free kick in the defensive half.
Goal! England 0, Hungary 3. Zsolt Nagy (Hungary) left footed shot from outside the box to the bottom left corner. Assisted by Martin Ádám.
Attempt blocked. Loic Nego (Hungary) header from the centre of the box is blocked. Assisted by Ádám Nagy with a cross.
Substitution, Hungary. Loic Nego replaces Roland Sallai.
