Manu Tuilagi has earned 46 caps for EnglandVenue: Twickenham Stadium Date: Saturday, 26 February Kick-off: 16:45 GMTCoverage: Listen to match commentary on BBC Radio 5 Live, BBC Radio Wales and BBC Radio Cymru; text commentary and highlights on BBC Sport website and app.Centre Manu Tuilagi will miss England's Six Nations match against Wales at Twickenham on Saturday after suffering a hamstring injury.
The 30-year-old was set to make his first appearance of this year's Championship after recovering from a similar injury.
He was named in the starting line-up earlier on Thursday, but was withdrawn having undergone scans after training.
Joe Marchant has been recalled and will train with the team on Friday.
England have said they will confirm the updated team to face Wales on the day of the match.
Before Tuilagi's injury, it was announced that Harry Randall will start at scrum-half, while fit-again Courtney Lawes was named as captain.
Tuilagi had been set to partner Henry Slade in the midfield.
His long history with injury has meant he has missed 79 possible matches since making his England debut in 2011 and the side has frequently struggled to find a suitable replacement in midfield.
Back after his most recent hamstring issue, Jones said Tuilagi "is a Test match winner", adding "you can't say that about too many players".
"We don't have any other centres like that with that weight, power and velocity with which they carry," Jones continued.
"He's unique for England."
Lawes injury 'nothing to do with my brain'
England are, however, bolstered by the return of experienced flanker Lawes, who resumes the captaincy with regular skipper Owen Farrell out for the tournament.
The Northampton forward said he "was worried about my head" when he first came into camp "not feeling great" after numerous incidents on the field.
But after seeing a specialist and getting a brain scan, Lawes told BBC Sport he was relieved to find it was "nothing to do with my brain".
Instead, an issue with his inner ear meant "the connection between eyes, ears and neck was a bit scrambled".
"It takes a bit of time to reset," Lawes explained.
"I feel really good now and I'm back to normal. I feel as good as I have for a while."
England lost their opening game against Scotland before a bonus-point win in Italy, meaning they realistically need victory against Wales to keep alive their title hopes.
Last year's winners Wales - who have recalled wing Josh Adams and number eight Taulupe Faletau for the game - have also won one and lost one of their fixtures so far.
Six Nations Rugby Special is on BBC Two from 18:20 on Sunday
