Manchester United made a winning start to life under interim boss Ralf Rangnick thanks to Fred's 77th-minute winner.
A more energetic United display looked like going unrewarded against a dogged Crystal Palace outfit until Fred struck first-time from Mason Greenwood's lay-off to send a superb 20-yard effort curling over Vicente Guaita and into the top corner.
It was only Fred's second goal of the season - and the first time since the middle of September that United have recorded back-to-back league wins.
Until the Brazilian's effort, Rangnick's side created numerous decent chances, without really looking as though they were going to score and Guaita would probably have saved an Alex Telles free-kick that skimmed the bar had it been on target.
Indeed Palace, who were looking to win for a third successive season at Old Trafford, came close themselves when Jordan Ayew turned James Tomkins header across the face of goal and narrowly wide of the far post.
The victory meant that Rangnick emulated three of United's other four new managers since Sir Alex Ferguson retired in 2013 by winning his first match at the helm, with Louis van Gaal the only man to fail.
More to follow.
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Manchester United
Squad number11Player nameGreenwoodSquad number34Player namevan de BeekSquad number36Player nameElangaCrystal Palace
Squad number13Player nameGuaita
Squad number17Player nameClyne
Squad number5Player nameTomkins
Squad number6Player nameGuéhi
Squad number3Player nameMitchell
Squad number15Player nameSchlupp
Squad number8Player nameKouyaté
Squad number23Player nameGallagher
Squad number9Player nameJ Ayew
Squad number20Player nameBenteke
Squad number11Player nameZaha
Squad number7Player nameOlise
Squad number10Player nameEze
Squad number22Player nameÉdouard
Line-ups
Man Utd
Formation 4-2-3-1
1de Gea
20Dalot2Lindelöf5Maguire27Telles
39McTominay17Fred
25Sancho18Bruno Fernandes10Rashford
7Cristiano Ronaldo
1de Gea20Dalot2LindelöfBooked at 90mins5Maguire27Telles39McTominayBooked at 81mins17Fred25SanchoSubstituted forGreenwoodat 62'minutes18Bruno FernandesSubstituted forvan de Beekat 86'minutes10RashfordSubstituted forElangaat 76'minutes7Cristiano RonaldoSubstitutes
3Bailly4Jones8Mata11Greenwood26Henderson29Wan-Bissaka31Matic34van de Beek36ElangaCrystal Palace
Formation 4-3-3
13Guaita
17Clyne5Tomkins6Guéhi3Mitchell
15Schlupp8Kouyaté23Gallagher
9J Ayew20Benteke11Zaha
13Guaita17ClyneBooked at 31mins5Tomkins6GuéhiBooked at 67mins3Mitchell15Schlupp8KouyatéSubstituted forEzeat 84'minutes23Gallagher9J AyewSubstituted forOliseat 84'minutes20BentekeSubstituted forÉdouardat 67'minutes11ZahaSubstitutes
1Butland4Milivojevic7Olise10Eze12Hughes14Mateta22Édouard34Kelly44RiedewaldLive Text
Match ends, Manchester United 1, Crystal Palace 0.
Second Half ends, Manchester United 1, Crystal Palace 0.
Dangerous play by Anthony Elanga (Manchester United).
Tyrick Mitchell (Crystal Palace) wins a free kick in the attacking half.
Corner, Crystal Palace. Conceded by Donny van de Beek.
Corner, Crystal Palace. Conceded by David de Gea.
Victor Lindelöf (Manchester United) is shown the yellow card for a bad foul.
Foul by Victor Lindelöf (Manchester United).
Wilfried Zaha (Crystal Palace) wins a free kick on the left wing.
Victor Lindelöf (Manchester United) wins a free kick in the attacking half.
Foul by Wilfried Zaha (Crystal Palace).
Corner, Manchester United. Conceded by Vicente Guaita.
Donny van de Beek (Manchester United) wins a free kick on the right wing.
Foul by James Tomkins (Crystal Palace).
Substitution, Manchester United. Donny van de Beek replaces Bruno Fernandes.
Foul by Mason Greenwood (Manchester United).
Jeffrey Schlupp (Crystal Palace) wins a free kick in the defensive half.
Substitution, Crystal Palace. Eberechi Eze replaces Cheikhou Kouyaté.
Substitution, Crystal Palace. Michael Olise replaces Jordan Ayew.
Scott McTominay (Manchester United) is shown the yellow card for a bad foul.
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