Watford earned a vital late point in their Premier League survival bid as Joao Pedro's headed equaliser kept them clear of the bottom three and denied hosts Newcastle a much-needed win.
Eddie Howe's side looked on course for only their second victory of the season after Allan Saint-Maximin's superb second-half goal.
But after Josh King and Pedro wasted chances for Claudio Ranieri's side, who always looked dangerous on the counter attack, the Brazilian forward rose above Jamaal Lascelles to nod in Kiko Femenia's cross and send the Watford fans wild.
The goal silenced the majority of St James' Park and led to Howe crashing a water bottle into the floor in frustration as they wasted a chance to move out of the relegation zone for the first time in 106 days.
But the draw was a reward for the visitors and Pedro, who continually caused a threat, with the Hornets remaining 17th.
Newcastle's plight was not helped by a Norwich win over Everton, as they remained 19th and Burnley slipped to the bottom of the table.
More to follow.
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Squad number1Player nameJosé Sá
Squad number23Player nameKilman
Squad number16Player nameCoady
Squad number24Player nameToti
Squad number22Player nameNélson Semedo
Squad number32Player nameDendoncker
Squad number28Player nameJoão Moutinho
Squad number3Player nameAït-Nouri
Squad number11Player nameTrincão
Squad number9Player nameJiménez
Squad number10Player nameDaniel Podence
Squad number17Player nameFábio Silva
Squad number37Player nameTraoré
Squad number39Player nameCundle
SouthamptonSquad number9Player nameA ArmstrongSquad number10Player nameAdamsSquad number17Player nameS Armstrong
21Fraser20Wood10Saint-Maximin1Dúbravka15Trippier6Lascelles5Schär3DummettBooked at 71mins36S Longstaff8ShelveyBooked at 6mins7Joelinton21FraserBooked at 53minsSubstituted forMurphyat 74'minutes20Wood10Saint-MaximinSubstituted forAlmirónat 86'minutes
25Dennis7King10João Pedro1Foster2NgakiaSubstituted forFemeníaat 66'minutes15Cathcart22SamirBooked at 90mins14Kamara39Kayembe19SissokoBooked at 51mins33KuckaSubstituted forCleverleyat 77'minutes25DennisSubstituted forHernándezat 84'minutes7King10João Pedro
Match ends, Newcastle United 1, Watford 1.
Second Half ends, Newcastle United 1, Watford 1.
Paul Dummett (Newcastle United) wins a free kick in the defensive half.
Foul by Joshua King (Watford).
Foul by Chris Wood (Newcastle United).
Samir (Watford) wins a free kick in the defensive half.
Corner, Watford. Conceded by Kieran Trippier.
Attempt blocked. João Pedro (Watford) right footed shot from outside the box is blocked. Assisted by Joshua King.
Samir (Watford) is shown the yellow card for a bad foul.
Chris Wood (Newcastle United) wins a free kick in the attacking half.
Goal! Newcastle United 1, Watford 1. João Pedro (Watford) header from the centre of the box to the bottom left corner. Assisted by Kiko Femenía with a cross.
Substitution, Newcastle United. Miguel Almirón replaces Allan Saint-Maximin.
Jacob Murphy (Newcastle United) wins a free kick in the defensive half.
Foul by Tom Cleverley (Watford).
Substitution, Watford. Cucho Hernández replaces Emmanuel Dennis.
Attempt missed. Jonjo Shelvey (Newcastle United) right footed shot from outside the box is too high. Assisted by Allan Saint-Maximin.
Attempt blocked. Kiko Femenía (Watford) right footed shot from outside the box is blocked.
Corner, Watford. Conceded by Paul Dummett.
Substitution, Watford. Tom Cleverley replaces Juraj Kucka.Our coverage of your Premier League club is bigger and better than ever before - here's everything you need to know to make sure you never miss a moment