Jill Roord (centre) played for Arsenal between 2019 and 2021Arsenal were knocked out of the Women's Champions League at the quarter-final stage after being beaten 3-1 on aggregate by Wolfsburg to end British interest in the competition.
The Londoners had salvaged a 1-1 draw late in the first leg at the Emirates last week, but were undone by goals in each half from the Frauen-Bundesliga leaders.
Former Gunner Jill Roord scored the opener after just eight minutes, hooking in from close range after the visitors failed to clear a corner.
The home side - playing at the men's team's Volkswagen Arena - thought they had netted again when Tabea Wassmuth stroked in but after a long check by VAR, it was ruled out for offside.
They did get a fortuitous second on 72 minutes when defender Leah Williamson inadvertently converted into her own net from Sveindis Jane Jonsdottir's low cross.
Arsenal pushed to find a way back into the tie but Vivianne Miedema's towering header struck the crossbar, before Williamson's follow-up was brilliantly tipped onto the post by goalkeeper Almuth Schult.
Victory for two-time champions Wolfsburg sets up a tantalising semi-final against current holders Barcelona.
The Spanish champions progressed on Wednesday following an 8-3 aggregate win over rivals Real Madrid, a match played at the Nou Camp in front of a world record crowd of 91,553.
Arsenal outclassed
Back-to-back winners of the competition in 2012-12 and 2013-14, Wolfsburg highlighted why they are top of the table in Germany by ousting the last remaining English side.
Tommy Stroot's team are locked in a tense title tussle, one point clear of Bayern Munich, while Arsenal themselves are fighting for the WSL crown, a point adrift of leaders Chelsea.
Though they still have an FA Cup semi-final to come next month against the Blues, their exploits in Europe came to an end for another campaign.
Arsenal won the trophy for the only time in 2007 and last reached the semi-finals nine years ago.
Kick-off in Germany was delayed by five minutes to clear confetti which had fallen on the pitch and ultimately it was Wolfsburg that were left celebrating in style.
They made the best possible start when Roord spun and converted inside the first 10 minutes and were much the better side in the opening period.
Jonsdottir fired over from the edge of the area and another cross from the left almost sailed in but was tipped over by Manuela Zinsberger.
The Arsenal goalkeeper was being kept busy and also made a sharp save to deny Svenja Huth's low drive.
They did eventually double their advantage in the second period with a helping hand from Williamson, poking in an own goal in between the legs of her team-mate.
At the other end, Miedema was on the periphery of the contest, hooking a shot over from an acute angle, while the Netherlands international was unable to turn home after Schult spilled a cross.
She came close to pulling a goal back when she struck the crossbar and, had that gone in, the tie would have seen a grandstand finish, but Wolfsburg comfortably saw the game out.
Line-ups
VfL Wolfsburg Ladies
Formation 4-4-2
1Schult
2Wilms4Hendrich6Janssen13Rauch
10Huth5Oberdorf8Lattwein32Jónsdóttir
28Waßmuth14Roord
1Schult2Wilms4Hendrich6Janssen13Rauch10Huth5OberdorfSubstituted forBlomqvistat 86'minutes8LattweinSubstituted forPoppat 45+3'minutes32JónsdóttirSubstituted forPajorat 79'minutes28Waßmuth14RoordSubstitutes
9Blässe11Popp16Starke17Pajor18Smits21Blomqvist22van de Sanden30Weiß31Cordes33Knaak77KiedrzynekArsenal Women
Formation 4-4-2
1Zinsberger
16Maritz6Williamson3Wubben-Moy7Catley
15McCabe12Maanum10Little77Heath
25Blackstenius11Miedema
1Zinsberger16MaritzSubstituted forWienroitherat 79'minutes6Williamson3Wubben-Moy7Catley15McCabeSubstituted forParrisat 71'minutes12MaanumSubstituted forNobbsat 71'minutes10Little77HeathSubstituted forFoordat 45'minutes25Blackstenius11MiedemaSubstitutes
5Beattie8Nobbs14Parris18Williams19Foord20Boye26Wienroither28CullLive Text
Match ends, VfL Wolfsburg Ladies 2, Arsenal Women 0.
Second Half ends, VfL Wolfsburg Ladies 2, Arsenal Women 0.
Foul by Lynn Wilms (VfL Wolfsburg Ladies).
Caitlin Foord (Arsenal Women) wins a free kick on the left wing.
Attempt saved. Jill Roord (VfL Wolfsburg Ladies) left footed shot from outside the box is saved in the top centre of the goal.
Offside, VfL Wolfsburg Ladies. Rebecka Blomqvist tries a through ball, but Svenja Huth is caught offside.
Attempt blocked. Rebecka Blomqvist (VfL Wolfsburg Ladies) right footed shot from outside the box is blocked.
Attempt saved. Jordan Nobbs (Arsenal Women) right footed shot from outside the box is saved in the top centre of the goal. Assisted by Lotte Wubben-Moy.
Corner, Arsenal Women. Conceded by Tabea Waßmuth.
Substitution, VfL Wolfsburg Ladies. Rebecka Blomqvist replaces Lena Oberdorf.
Lynn Wilms (VfL Wolfsburg Ladies) wins a free kick on the right wing.
Foul by Caitlin Foord (Arsenal Women).
Offside, VfL Wolfsburg Ladies. Alexandra Popp tries a through ball, but Ewa Pajor is caught offside.
Foul by Tabea Waßmuth (VfL Wolfsburg Ladies).
Stephanie-Elise Catley (Arsenal Women) wins a free kick on the left wing.
Attempt blocked. Kim Little (Arsenal Women) right footed shot from outside the box is blocked.
Attempt saved. Lena Oberdorf (VfL Wolfsburg Ladies) right footed shot from outside the box is saved in the bottom right corner. Assisted by Felicitas Rauch.
Substitution, Arsenal Women. Laura Wienroither replaces Noëlle Maritz.
Substitution, VfL Wolfsburg Ladies. Ewa Pajor replaces Sveindís Jónsdóttir.
Corner, Arsenal Women. Conceded by Alexandra Popp.
